GRIA2

Across TCGA cell cohorts, GRIA2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,175 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRIA2-associated GO terms across cancer lineages are Negative regulation of mRNA splicing, via spliceosome, Establishment of protein localization to organelle, and Negative regulation of mRNA processing. Each is linked with GRIA2 in more than 8 cancer types. Because this analysis shows association rather than direction, both GRIA2-to-partner and partner-to-GRIA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of mRNA splicing, via spliceosome grouped by GRIA2-low versus GRIA2-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIA2→partner) and Y-score (partner→GRIA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of mRNA splicing, via spliceosome →	+0.061	+0.036	.001	<.001	3	9
SKIN	Establishment of protein localization to organelle →	+0.042	+0.679	<.001	.004	3	8
PANCREAS	Negative regulation of mRNA processing →	+0.061	+0.036	.001	<.001	3	8
SKIN	mRNA splice site recognition →	+0.084	+0.676	<.001	.004	3	7
PANCREAS	RNA catabolic process →	+0.037	+0.037	<.001	<.001	3	7
KIDNEY	Protein stabilization →	+0.045	+0.099	.001	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,175 associations by consensus.

Negative regulation of mRNA splicing, via spliceosome by GRIA2 expression — PANCREAS

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