GRIA2

Across TCGA cell cohorts, GRIA2 mutation is significantly associated with the RNA expression of many other genes, with 892 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRIA2-associated genes across cancer lineages are CCR8, ORC2, and SLC25A51. Each is linked with GRIA2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRIA2-to-partner and partner-to-GRIA2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCR8 grouped by GRIA2-low versus GRIA2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRIA2→partner) and Y-score (partner→GRIA2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CCR8 →	+0.022	+5.369	<.001	.004	3	2
LARGE_INTESTINE	ORC2 →	+0.488	+2.447	.001	.006	3	2
LARGE_INTESTINE	SLC25A51 →	+0.626	+2.628	<.001	.002	3	2
LARGE_INTESTINE	CEP85 →	+0.636	+3.386	.006	.001	3	2
LARGE_INTESTINE	IPO8 →	+0.643	+3.523	<.001	<.001	3	2
LARGE_INTESTINE	CHMP7 →	+0.707	+3.169	.003	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 892 associations by consensus.

CCR8 by GRIA2 expression — SOFT_TISSUE

Explore this box plot interactively →