GRHL3

Across TCGA patient cohorts, GRHL3 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRHL3-associated genes across cancer lineages are Caspase-8, C-Raf, and EGFR_pY1068. Each is linked with GRHL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both GRHL3-to-partner and partner-to-GRHL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by GRHL3-low versus GRHL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRHL3→partner) and Y-score (partner→GRHL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.312	-3.673	.002	.001	3	3
UCEC	C-Raf →	+0.216	+2.906	<.001	.001	3	3
UCEC	EGFR_pY1068 →	-0.306	-3.321	.002	.009	3	2
UCEC	JNK2 →	+0.224	+2.331	.005	.019	3	2
UCEC	ASNS →	+0.520	+2.415	<.001	.003	3	2
UCEC	Cyclin-B1 →	+0.726	+2.584	.001	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Caspase-8 by GRHL3 expression — UCEC

Explore this box plot interactively →