GRHL3

Across TCGA cell cohorts, GRHL3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,843 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible GRHL3-associated GO terms across cancer lineages are Response to indole-3-methanol, Cellular response to indole-3-methanol, and Mammary gland development. Each is linked with GRHL3 in more than 11 cancer types. Because this analysis shows association rather than direction, both GRHL3-to-partner and partner-to-GRHL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to indole-3-methanol grouped by GRHL3-low versus GRHL3-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GRHL3→partner) and Y-score (partner→GRHL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Response to indole-3-methanol →	+0.267	+2.304	<.001	<.001	3	12
URINARY_TRACT	Cellular response to indole-3-methanol →	+0.225	+3.202	<.001	<.001	3	12
URINARY_TRACT	Mammary gland development →	+0.202	+3.245	<.001	<.001	3	10
OVARY	Cell-cell adhesion mediated by cadherin →	+0.188	+1.305	<.001	<.001	3	10
STOMACH	Desmosome assembly →	+0.443	+2.031	.005	<.001	3	10
PANCREAS	Protein localization to bicellular tight junction →	+0.151	+1.215	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,843 associations by consensus.

Response to indole-3-methanol by GRHL3 expression — STOMACH

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