GRHL3-AS1

Across TCGA pan-cancer cohorts, GRHL3-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated GRHL3-AS1 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GRHL3-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated GRHL3-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCS show a favorable association.

HNSC, UCS, and UCEC are the cancer types where GRHL3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.810	0.690	<.001	150	view →
UCS	OS	Tertile	III,IV	0.763	0.321	.007	60	view →
UCEC	OS	Median	III,IV	0.898	0.760	.002	52	view →
READ	DFS	Median	All	0.378	0.761	.001	41	view →
KIRP	DFS	Median	All	0.955	0.864	.002	30	view →
LUSC	OS	Tertile	All	0.754	0.608	.005	22	view →
THCA	DFS	Median	III,IV	0.575	0.826	.006	21	view →
LIHC	DFS	Quartile	III,IV	0.134	0.514	<.001	14	view →
OV	OS	Tertile	IV	0.576	0.826	.016	12	view →
ESCA	DFS	Tertile	All	0.218	0.428	.023	12	view →
ACC	OS	Tertile	II,III,IV	1.000	0.802	.032	12	view →
COAD	DFS	Quartile	III,IV	0.509	0.680	.014	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

GRHL3-AS1–HNSC (OS)

Open the HNSC breakdown →