GREM2

Across TCGA pan-cancer cohorts, GREM2 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GREM2 data layer compared with 23 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher GREM2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated GREM2 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LUSC, LGG, and LUAD are the cancer types where GREM2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	All	0.079	0.792	<.001	30	view →
LGG	OS	Median	All	0.307	0.811	.008	6	view →
LUAD	OS	Median	III,IV	1.000	0.275	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

GREM2–LUSC (DFS)

Open the LUSC breakdown →