GREM2

Across TCGA patient cohorts, GREM2 protein abundance is significantly associated with the protein abundance of many other proteins, with 4,738 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GREM2-associated proteins across cancer lineages are RNF146_S294, SPEG_S2496, and ADD1. Each is linked with GREM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GREM2-to-partner and partner-to-GREM2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GREM2 versus RNF146_S294 in UCEC, with a Pearson correlation of 0.65.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GREM2→partner) and Y-score (partner→GREM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNF146_S294 →	+1.525	+2.414	<.001	.004	3	2
UCEC	SPEG_S2496 →	+1.174	+2.888	<.001	<.001	3	2
UCEC	ADD1 →	+0.409	+2.000	<.001	<.001	3	2
UCEC	DES_S28 →	+0.862	+1.211	.001	.002	3	2
LSCC	ELL_S442 →	-0.721	-0.628	.004	<.001	3	2
HNSC	KCTD12_S187 →	+1.054	+1.134	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,738 associations by consensus.

GREM2 vs RNF146_S294 — UCEC

Explore this scatter interactively →