GREM2

Across TCGA patient cohorts, GREM2 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GREM2-associated genes across cancer lineages are c-Met_pY1235, Stathmin, and HER3_pY1289. Each is linked with GREM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both GREM2-to-partner and partner-to-GREM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by GREM2-low versus GREM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GREM2→partner) and Y-score (partner→GREM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.086	+2.321	.021	.035	3	3
UCEC	Stathmin →	+0.146	+2.321	.034	.035	3	2
UCEC	HER3_pY1289 →	+0.107	+2.827	.013	.035	2	2
UCEC	mTOR_pS2448 →	-0.158	-2.321	.035	.035	3	1
UCEC	Notch1 →	+0.298	+3.009	<.001	.019	3	1
UCEC	Rab25 →	-0.374	-3.000	.024	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

c-Met_pY1235 by GREM2 expression — UCEC

Explore this box plot interactively →