GREM2

Across TCGA cell cohorts, GREM2 mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible GREM2-associated genes across cancer lineages are TAFA1, MAGEB10, and TEX53. Each is linked with GREM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GREM2-to-partner and partner-to-GREM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAFA1 grouped by GREM2-low versus GREM2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GREM2→partner) and Y-score (partner→GREM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TAFA1 →	+0.709	+4.149	<.001	.003	3	2
LARGE_INTESTINE	MAGEB10 →	+0.087	+3.930	<.001	.003	3	1
LARGE_INTESTINE	TEX53 →	+0.105	+3.684	<.001	.006	3	1
SKIN	MINAR2 →	+0.013	+4.977	<.001	.007	3	1
BLOOD_Lymphoma	KLHL40 →	+0.006	+5.209	.006	.005	3	1
CNS	F9 →	+0.022	+5.321	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

TAFA1 by GREM2 expression — BLOOD_Leukemia

Explore this box plot interactively →