GREM2

Across TCGA cell cohorts, GREM2 mutation is significantly associated with the mutation status of many other genes, with 2,566 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GREM2-associated genes across cancer lineages are BRPF1, PRDM16, and DDN. Each is linked with GREM2 in more than 3 cancer types. Because this analysis shows association rather than direction, both GREM2-to-partner and partner-to-GREM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BRPF1 grouped by GREM2-low versus GREM2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GREM2→partner) and Y-score (partner→GREM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BRPF1 →	+2.874	+3.632	.002	.002	1	4
STOMACH	PRDM16 →	+4.807	+4.807	.008	.008	1	4
LUNG_SCLC	DDN →	+4.307	+4.307	.001	.001	1	3
CNS	KAZN →	+4.459	+5.277	.005	.005	1	3
CNS	INTS6 →	+4.459	+5.277	.005	.005	1	3
CNS	TSGA10 →	+4.044	+5.000	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,566 associations by consensus.

BRPF1 by GREM2 expression — LARGE_INTESTINE

Explore this box plot interactively →