GREM1

Across TCGA patient cohorts, GREM1 protein abundance is significantly associated with the RNA expression of many other genes, with 8,842 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible GREM1-associated genes across cancer lineages are VGLL3, CCDC80, and SYNDIG1. Each is linked with GREM1 in more than 7 cancer types. Because this analysis shows association rather than direction, both GREM1-to-partner and partner-to-GREM1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GREM1 versus VGLL3 in CCRCC, with a Pearson correlation of 0.68.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GREM1→partner) and Y-score (partner→GREM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	VGLL3 →	+1.294	+1.888	.002	.005	3	7
CCRCC	CCDC80 →	+2.144	+1.874	.001	.003	2	8
BRCA	SYNDIG1 →	+1.353	+0.693	<.001	<.001	3	7
PDAC	MEDAG →	+1.439	+0.967	<.001	<.001	3	7
LUAD	CILP →	+1.643	+1.031	<.001	<.001	3	7
UCEC	PDLIM3 →	+1.956	+1.287	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,842 associations by consensus.

GREM1 vs VGLL3 — CCRCC

Explore this scatter interactively →