GREM1

Across TCGA patient cohorts, GREM1 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GREM1-associated genes across cancer lineages are ATM, eEF2, and A-Raf_pS299. Each is linked with GREM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both GREM1-to-partner and partner-to-GREM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by GREM1-low versus GREM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GREM1→partner) and Y-score (partner→GREM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.512	-2.209	.001	.009	3	2
UCEC	eEF2 →	+0.353	+3.459	.004	.005	3	1
UCEC	A-Raf_pS299 →	-0.163	-3.700	<.001	.001	3	1
UCEC	FoxM1 →	+0.218	+1.440	.015	.024	3	1
UCEC	FOXO3a_pS318_S321 →	-0.131	-2.077	.002	.005	3	1
UCEC	GAPDH →	+0.399	+1.584	.032	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

ATM by GREM1 expression — UCEC

Explore this box plot interactively →