Across TCGA pan-cancer cohorts, GREB1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated GREB1 data layer compared with 22 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher GREB1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GREB1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

LSCC, CCRCC, and GBM are the cancer types where GREB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.611	0.920	.010	12	view →
CCRCC	DFS	Median	III,IV	0.789	0.252	.036	10	view →
GBM	OS	Tertile	All	0.295	0.622	.010	4	view →
LUAD	OS	Median	All	1.000	0.318	.019	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: GREB1 tumor-vs-normal RNA expression · all GREB1 data types