Across TCGA patient cohorts, GREB1 mutation is significantly associated with the RNA expression of many other genes, with 6,185 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GREB1-associated genes across cancer lineages are POLE2, PARP2, and PAK1IP1. Each is linked with GREB1 in more than 5 cancer types. Because this analysis shows association rather than direction, both GREB1-to-partner and partner-to-GREB1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GREB1→partner) and Y-score (partner→GREB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	POLE2 →	+0.579	+2.923	<.001	<.001	3	6
LUSC	PARP2 →	+0.442	+2.526	.001	.001	3	6
STAD	PAK1IP1 →	+0.514	+2.289	.001	.005	3	5
STAD	SNRPA1 →	+0.406	+2.923	.005	<.001	3	5
STAD	CHAF1B →	+0.586	+3.371	.002	.004	3	5
STAD	PCLAF →	+0.667	+3.471	.004	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,185 associations by consensus.

Exploration

GREB1 survival (RNA) · tumor vs normal (RNA) · all GREB1 data types