GRB7

Across TCGA cell cohorts, GRB7 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,047 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible GRB7-associated GO terms across cancer lineages are Negative regulation of Arp2/3 complex-mediated actin nucleation, Establishment of epithelial cell apical/basal polarity, and Response to indole-3-methanol. Each is linked with GRB7 in more than 14 cancer types. Because this analysis shows association rather than direction, both GRB7-to-partner and partner-to-GRB7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of Arp2/3 complex-mediated actin nucleation grouped by GRB7-low versus GRB7-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GRB7→partner) and Y-score (partner→GRB7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of Arp2/3 complex-mediated actin nucleation →	+0.234	+2.122	<.001	<.001	3	15
LUNG_NSCLC_LUSC	Establishment of epithelial cell apical/basal polarity →	-0.230	-2.451	<.001	.003	3	13
LUNG_NSCLC_LUSC	Response to indole-3-methanol →	+0.260	+2.565	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Cellular response to indole-3-methanol →	+0.217	+2.402	<.001	<.001	2	13
OESOPHAGUS	Sensory perception of salty taste →	+1.857	+4.761	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Maintenance of blood-brain barrier →	+0.246	+2.603	<.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,047 associations by consensus.

Negative regulation of Arp2/3 complex-mediated actin nucleation by GRB7 expression — LUNG_SCLC

Explore this box plot interactively →