GRB7

Across TCGA cell cohorts, GRB7 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GRB7-associated genes across cancer lineages are LGI1, C20orf85, and IL22. Each is linked with GRB7 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRB7-to-partner and partner-to-GRB7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LGI1 grouped by GRB7-low versus GRB7-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRB7→partner) and Y-score (partner→GRB7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LGI1 →	+0.096	+4.539	<.001	.007	3	1
BLOOD_Leukemia	C20orf85 →	+0.036	+4.969	<.001	.003	3	1
BLOOD_Leukemia	IL22 →	+0.037	+5.569	<.001	.001	3	1
BLOOD_Leukemia	HTR5A →	+0.032	+4.409	.002	.005	3	1
BLOOD_Leukemia	CALHM4 →	+0.038	+5.269	<.001	<.001	3	1
BLOOD_Leukemia	FAM71B →	+0.029	+5.060	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

LGI1 by GRB7 expression — BLOOD_Leukemia

Explore this box plot interactively →