GRB2

Across TCGA patient cohorts, GRB2 protein abundance is significantly associated with the RNA expression of many other genes, with 15,643 significant associations in total. GBM shows the largest number of these associations.

The most reproducible GRB2-associated genes across cancer lineages are LPXN, SCIMP, and PYHIN1. Each is linked with GRB2 in more than 9 cancer types. Because this analysis shows association rather than direction, both GRB2-to-partner and partner-to-GRB2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GRB2 versus LPXN in UCEC, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRB2→partner) and Y-score (partner→GRB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LPXN →	+0.748	+0.273	<.001	<.001	3	10
UCEC	SCIMP →	+0.692	+0.354	<.001	<.001	3	10
HNSC	PYHIN1 →	+0.904	+0.264	<.001	<.001	3	10
UCEC	AIM2 →	+1.355	+0.387	<.001	<.001	3	10
UCEC	C1QB →	+1.550	+0.321	<.001	<.001	3	10
OV	SLAMF7 →	+1.227	+0.383	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,643 associations by consensus.

GRB2 vs LPXN — UCEC

Explore this scatter interactively →