GRB2

Across TCGA patient cohorts, GRB2 mutation is significantly associated with the RNA expression of many other genes, with 868 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRB2-associated genes across cancer lineages are FCER1A, CCDC43, and ARHGAP45. Each is linked with GRB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRB2-to-partner and partner-to-GRB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FCER1A grouped by GRB2-low versus GRB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRB2→partner) and Y-score (partner→GRB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FCER1A →	-0.803	-3.435	.008	.005	3	1
UCEC	CCDC43 →	+0.582	+3.491	.003	.002	3	1
UCEC	ARHGAP45 →	+0.767	+3.700	.001	.001	3	1
UCEC	GPR157 →	+1.055	+3.191	<.001	.009	3	1
UCEC	HOXC9 →	+1.456	+2.595	.003	.006	3	1
UCEC	LINC01559 →	+0.621	+2.617	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 868 associations by consensus.

FCER1A by GRB2 expression — UCEC

Explore this box plot interactively →