GRB2

Across TCGA patient cohorts, GRB2 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRB2-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and ACC_pS79. Each is linked with GRB2 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRB2-to-partner and partner-to-GRB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by GRB2-low versus GRB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRB2→partner) and Y-score (partner→GRB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.140	-3.143	.002	.018	3	1
UCEC	EGFR_pY1068 →	-0.280	-2.321	.016	.034	3	1
UCEC	ACC_pS79 →	+0.549	+2.584	<.001	.011	3	1
UCEC	MEK1 →	+0.406	+3.169	.017	.019	3	1
UCEC	N-Ras →	-0.167	-2.302	.002	.034	3	1
UCEC	p62 Lck ligand →	+0.483	+3.700	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

14-3-3_beta by GRB2 expression — UCEC

Explore this box plot interactively →