GRB14

Across TCGA patient cohorts, GRB14 mutation is significantly associated with the RNA expression of many other genes, with 1,157 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRB14-associated genes across cancer lineages are RNA5SP213, TAF9, and RNA5SP412. Each is linked with GRB14 in more than 2 cancer types. Because this analysis shows association rather than direction, both GRB14-to-partner and partner-to-GRB14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP213 grouped by GRB14-low versus GRB14-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRB14→partner) and Y-score (partner→GRB14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNA5SP213 →	+0.072	+3.903	<.001	.007	3	3
UCEC	TAF9 →	+0.539	+2.906	<.001	.001	3	2
UCEC	RNA5SP412 →	+0.713	+2.266	<.001	.001	3	2
UCEC	FAM151B →	+0.328	+2.098	<.001	.003	3	2
UCEC	DFFA →	+0.497	+2.163	<.001	.009	3	2
UCEC	LMNB2 →	+0.686	+2.330	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,157 associations by consensus.

RNA5SP213 by GRB14 expression — SKCM

Explore this box plot interactively →