GRB14

Across TCGA patient cohorts, GRB14 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRB14-associated genes across cancer lineages are ERK2, PRDX1, and 4E-BP1. Each is linked with GRB14 in more than 2 cancer types. Because this analysis shows association rather than direction, both GRB14-to-partner and partner-to-GRB14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by GRB14-low versus GRB14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRB14→partner) and Y-score (partner→GRB14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.188	+2.222	.021	.011	3	2
SKCM	PRDX1 →	+0.318	+2.321	.029	.035	2	3
UCEC	4E-BP1 →	+0.336	+3.029	.003	.018	3	2
SKCM	Bcl-2 →	+0.385	+2.321	.031	.035	3	2
UCEC	14-3-3_beta →	-0.100	-3.143	.018	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.203	-3.169	.004	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

ERK2 by GRB14 expression — UCEC

Explore this box plot interactively →