GRB14

Across TCGA cell cohorts, GRB14 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible GRB14-associated genes across cancer lineages are GAGE10, H2BC1, and PANX3. Each is linked with GRB14 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRB14-to-partner and partner-to-GRB14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE10 grouped by GRB14-low versus GRB14-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRB14→partner) and Y-score (partner→GRB14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	GAGE10 →	+0.073	+3.882	<.001	.004	3	2
SOFT_TISSUE	H2BC1 →	+0.260	+4.392	<.001	.004	3	1
SOFT_TISSUE	PANX3 →	+0.422	+4.295	<.001	.002	3	1
SOFT_TISSUE	H2AC1 →	+0.115	+4.392	<.001	.004	3	1
SOFT_TISSUE	IL25 →	+0.012	+4.392	<.001	.004	3	1
SOFT_TISSUE	GOLGA6C →	+0.034	+3.999	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

GAGE10 by GRB14 expression — SOFT_TISSUE

Explore this box plot interactively →