GRB10

Across TCGA pan-cancer cohorts, GRB10 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated GRB10 data layer compared with 27 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher GRB10 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GRB10 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

KIRC, STAD, and HNSC are the cancer types where GRB10 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.067	0.874	<.001	36	view →
STAD	OS	Median	IV	0.001	0.544	<.001	12	view →
HNSC	DFS	Median	IV	0.101	0.670	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUAD	DFS	Median	All	1.000	0.657	.025	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

GRB10–KIRC (OS)

Open the KIRC breakdown →