GRB10

Across TCGA patient cohorts, GRB10 protein abundance is significantly associated with the protein abundance of many other proteins, with 14,970 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible GRB10-associated proteins across cancer lineages are GRB10_S104, GRB10_S150, and MAP1B_S1427. Each is linked with GRB10 in more than 8 cancer types. Because this analysis shows association rather than direction, both GRB10-to-partner and partner-to-GRB10 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GRB10 versus GRB10_S104 in LUAD, with a Pearson correlation of 0.85.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GRB10→partner) and Y-score (partner→GRB10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GRB10_S104 →	+1.119	+0.574	<.001	<.001	3	9
BRCA	GRB10_S150 →	+1.039	+0.439	<.001	<.001	3	8
LUAD	MAP1B_S1427 →	+1.133	+0.646	<.001	<.001	3	4
CCRCC	ACAP1 →	-0.554	-0.562	<.001	<.001	3	3
HNSC	ARHGAP9_S113 →	-0.625	-0.508	<.001	<.001	3	3
BRCA	CCDC12 →	-0.292	-0.347	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,970 associations by consensus.

GRB10 vs GRB10_S104 — LUAD

Explore this scatter interactively →