GRB10

Across TCGA patient cohorts, GRB10 mutation is significantly associated with the RNA expression of many other genes, with 2,814 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRB10-associated genes across cancer lineages are RPL23AP97, SLC20A1P2, and MYO5BP1. Each is linked with GRB10 in more than 2 cancer types. Because this analysis shows association rather than direction, both GRB10-to-partner and partner-to-GRB10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL23AP97 grouped by GRB10-low versus GRB10-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRB10→partner) and Y-score (partner→GRB10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPL23AP97 →	+0.734	+3.516	<.001	.002	3	3
BRCA	SLC20A1P2 →	+0.139	+4.337	<.001	.007	3	2
BRCA	MYO5BP1 →	+0.041	+4.209	.008	.009	3	2
BRCA	MIR6821 →	+0.630	+4.243	<.001	.009	3	2
UCEC	ZNF280B →	+0.396	+1.496	.001	.002	3	2
UCEC	PIGW →	+0.475	+1.917	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,814 associations by consensus.

RPL23AP97 by GRB10 expression — SKCM

Explore this box plot interactively →