GRB10

Across TCGA patient cohorts, GRB10 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRB10-associated genes across cancer lineages are Bad_pS112, ATM, and Caspase-8. Each is linked with GRB10 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRB10-to-partner and partner-to-GRB10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bad_pS112 grouped by GRB10-low versus GRB10-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRB10→partner) and Y-score (partner→GRB10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Bad_pS112 →	+0.266	+2.820	.008	.035	3	2
UCEC	ATM →	-0.423	-1.652	.004	.006	3	2
UCEC	Caspase-8 →	-0.273	-2.636	<.001	<.001	3	2
UCEC	Cyclin-E2 →	+0.111	+1.652	.045	.006	3	2
SKCM	IRS1 →	+0.222	+2.824	.007	.034	3	1
SKCM	PKC-delta_pS664 →	+0.267	+3.169	.008	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Bad_pS112 by GRB10 expression — SKCM

Explore this box plot interactively →