GRB10

Across TCGA cell cohorts, GRB10 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,993 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible GRB10-associated GO terms across cancer lineages are Positive regulation of cytoplasmic translation, Regulation of myoblast fusion, and Cellular response to insulin stimulus. Each is linked with GRB10 in more than 9 cancer types. Because this analysis shows association rather than direction, both GRB10-to-partner and partner-to-GRB10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cytoplasmic translation grouped by GRB10-low versus GRB10-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GRB10→partner) and Y-score (partner→GRB10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of cytoplasmic translation →	+0.124	+1.623	<.001	.003	3	10
LUNG_SCLC	Regulation of myoblast fusion →	+0.091	+1.660	.003	.009	2	9
CNS	Cellular response to insulin stimulus →	+0.036	+1.430	<.001	.001	3	8
LUNG_NSCLC_LUAD	Neuropilin signaling pathway →	+0.181	+1.801	<.001	<.001	3	8
PANCREAS	Cotranslational protein targeting to membrane →	+0.099	+2.036	.003	.001	3	8
BONE	Response to oscillatory fluid shear stress →	+0.124	+1.917	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,993 associations by consensus.

Positive regulation of cytoplasmic translation by GRB10 expression — LUNG_SCLC

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