GRB10

Across TCGA cell cohorts, GRB10 mutation is significantly associated with the drug of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRB10-associated genes across cancer lineages are Nutlin-3a (-), Niraparib, and AZD5153. Each is linked with GRB10 in more than 1 cancer types. Because this analysis shows association rather than direction, both GRB10-to-partner and partner-to-GRB10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nutlin-3a (-) grouped by GRB10-low versus GRB10-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRB10→partner) and Y-score (partner→GRB10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Nutlin-3a (-) →	+0.737	+2.646	.045	.047	3	1
LARGE_INTESTINE	Niraparib →	+0.464	+2.646	.008	.047	3	1
LARGE_INTESTINE	AZD5153 →	+0.567	+2.649	.024	.046	3	1
LARGE_INTESTINE	JAK1_8709 →	+0.403	+2.649	.042	.046	3	1
LARGE_INTESTINE	Y-39983 →	+0.575	+2.652	.007	.045	3	1
LARGE_INTESTINE	Torin 2 →	+0.602	+2.655	.024	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Nutlin-3a (-) by GRB10 expression — LARGE_INTESTINE

Explore this box plot interactively →