GRAP

Across TCGA pan-cancer cohorts, GRAP mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated GRAP data layer compared with 28 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GRAP mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated GRAP expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and HNSC are the cancer types where GRAP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	1.000	0.650	.001	46	view →
PDAC	OS	Quartile	All	0.821	0.307	<.001	36	view →
HNSC	OS	Median	All	1.000	0.484	.038	12	view →
LUAD	DFS	Quartile	All	0.825	0.429	<.001	9	view →
LSCC	DFS	Tertile	II,III,IV	0.872	1.000	.032	5	view →
UCEC	DFS	Quartile	All	1.000	0.858	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

GRAP–CCRCC (OS)

Open the CCRCC breakdown →