GRAP

Across TCGA patient cohorts, GRAP protein abundance is significantly associated with the RNA expression of many other genes, with 16,570 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GRAP-associated genes across cancer lineages are CCDC69, RCSD1, and SENCR. Each is linked with GRAP in more than 7 cancer types. Because this analysis shows association rather than direction, both GRAP-to-partner and partner-to-GRAP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GRAP versus CCDC69 in LSCC, with a Pearson correlation of 0.76.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRAP→partner) and Y-score (partner→GRAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CCDC69 →	+1.045	+0.590	<.001	<.001	3	8
LSCC	RCSD1 →	+0.848	+0.555	<.001	<.001	3	8
HNSC	SENCR →	+0.687	+0.344	<.001	<.001	3	8
HNSC	ABCA8 →	+1.118	+0.397	<.001	<.001	3	7
CCRCC	DNASE1L3 →	+1.429	+0.499	<.001	<.001	3	7
CCRCC	LDB2 →	+1.173	+0.558	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,570 associations by consensus.

GRAP vs CCDC69 — LSCC

Explore this scatter interactively →