GRAP

Across TCGA patient cohorts, GRAP mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRAP-associated genes across cancer lineages are RPS29P26, LRRC30, and IGLJ4. Each is linked with GRAP in more than 1 cancer types. Because this analysis shows association rather than direction, both GRAP-to-partner and partner-to-GRAP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS29P26 grouped by GRAP-low versus GRAP-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRAP→partner) and Y-score (partner→GRAP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPS29P26 →	+0.718	+7.816	<.001	.008	3	1
LUAD	LRRC30 →	+0.039	+7.930	<.001	.008	3	1
LUAD	IGLJ4 →	+0.722	+7.930	<.001	.008	3	1
LUAD	RNA5SP286 →	+0.297	+7.930	<.001	.008	3	1
LUAD	CDY8P →	+0.029	+7.930	<.001	.008	3	1
LUAD	RNU6-966P →	+0.303	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

RPS29P26 by GRAP expression — SKCM

Explore this box plot interactively →