GRAMD4P6

Across TCGA pan-cancer cohorts, GRAMD4P6 RNA is linked to patient survival in 12 of 34 cancer types, making it the most broadly survival-associated GRAMD4P6 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher GRAMD4P6 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated GRAMD4P6 expression acts as an unfavorable survival marker, although some lineages such as SKCM show a favorable association.

KIRC, LUSC, and UCEC are the cancer types where GRAMD4P6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	II,III,IV	0.425	0.809	<.001	120	view →
LUSC	DFS	Tertile	II,III,IV	0.140	0.720	<.001	99	view →
UCEC	OS	Tertile	All	0.125	0.679	.002	90	view →
ACC	OS	Tertile	All	0.114	0.892	<.001	72	view →
COAD	OS	Tertile	All	0.145	0.871	<.001	63	view →
UVM	OS	Tertile	All	0.220	0.917	<.001	54	view →
KIRP	DFS	Tertile	II,III,IV	0.038	0.783	<.001	54	view →
BLCA	OS	Tertile	All	0.174	0.720	<.001	36	view →
HNSC	OS	Tertile	II,III,IV	0.215	0.600	.040	27	view →
LUAD	OS	Tertile	All	0.238	0.697	.015	27	view →
LIHC	OS	Tertile	All	0.164	0.688	.030	18	view →
SKCM	DFS	Tertile	All	1.000	0.614	.034	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 12 lineages.

GRAMD4P6–KIRC (OS)

Open the KIRC breakdown →