GRAMD4

Across TCGA patient cohorts, GRAMD4 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRAMD4-associated genes across cancer lineages are ASNS, ATM, and Chk2_pT68. Each is linked with GRAMD4 in more than 2 cancer types. Because this analysis shows association rather than direction, both GRAMD4-to-partner and partner-to-GRAMD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by GRAMD4-low versus GRAMD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRAMD4→partner) and Y-score (partner→GRAMD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.322	+2.000	.007	.009	3	3
UCEC	ATM →	-0.595	-1.874	<.001	.002	3	2
UCEC	Chk2_pT68 →	-0.142	-2.558	.023	.010	3	2
UCEC	EGFR_pY1068 →	-0.250	-1.584	.002	.009	3	1
UCEC	eIF4E →	+0.158	+2.598	.025	.005	3	1
UCEC	ERK2 →	+0.184	+1.584	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ASNS by GRAMD4 expression — UCEC

Explore this box plot interactively →