GRAMD4

Across TCGA cell cohorts, GRAMD4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,004 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible GRAMD4-associated GO terms across cancer lineages are Lactate metabolic process, Regulation of low-density lipoprotein particle receptor catabolic process, and Negative regulation of toll-like receptor 9 signaling pathway. Each is linked with GRAMD4 in more than 12 cancer types. Because this analysis shows association rather than direction, both GRAMD4-to-partner and partner-to-GRAMD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lactate metabolic process grouped by GRAMD4-low versus GRAMD4-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GRAMD4→partner) and Y-score (partner→GRAMD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Lactate metabolic process →	-0.185	-0.960	<.001	<.001	3	13
BLOOD_Myeloma	Regulation of low-density lipoprotein particle receptor catabolic process →	+0.184	+1.662	.004	.005	3	13
SKIN	Negative regulation of toll-like receptor 9 signaling pathway →	+0.177	+1.346	<.001	<.001	3	13
BONE	Copper ion export →	-0.173	-1.420	.003	.002	3	12
SKIN	Glycerophospholipid metabolic process →	+0.048	+1.660	<.001	<.001	3	12
BONE	Pre-mRNA catabolic process →	+0.139	+0.999	.007	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,004 associations by consensus.

Lactate metabolic process by GRAMD4 expression — BREAST

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