GRAMD2B

Across TCGA patient cohorts, GRAMD2B mutation is significantly associated with the RNA expression of many other genes, with 1,115 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRAMD2B-associated genes across cancer lineages are LARP7P3, OR7H1P, and NF1P4. Each is linked with GRAMD2B in more than 2 cancer types. Because this analysis shows association rather than direction, both GRAMD2B-to-partner and partner-to-GRAMD2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LARP7P3 grouped by GRAMD2B-low versus GRAMD2B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRAMD2B→partner) and Y-score (partner→GRAMD2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	LARP7P3 →	+0.491	+4.614	<.001	.006	3	3
LIHC	OR7H1P →	+0.046	+4.758	<.001	.006	3	2
BLCA	NF1P4 →	+0.106	+4.533	<.001	.005	3	2
UCEC	RNA5SP405 →	+0.306	+3.260	<.001	.004	3	2
UCEC	RNU6-508P →	+0.285	+3.132	<.001	.005	3	2
UCEC	TRAJ43 →	+0.639	+1.973	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,115 associations by consensus.

LARP7P3 by GRAMD2B expression — SKCM

Explore this box plot interactively →