GRAMD2B

Across TCGA patient cohorts, GRAMD2B mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRAMD2B-associated genes across cancer lineages are eIF4E, MEK1, and eEF2. Each is linked with GRAMD2B in more than 1 cancer types. Because this analysis shows association rather than direction, both GRAMD2B-to-partner and partner-to-GRAMD2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by GRAMD2B-low versus GRAMD2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRAMD2B→partner) and Y-score (partner→GRAMD2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.197	+2.700	.038	.006	3	2
UCEC	MEK1 →	+0.409	+2.700	.013	.006	3	2
UCEC	eEF2 →	+0.362	+2.000	.024	.032	3	1
UCEC	EGFR_pY1068 →	-0.303	-2.700	.007	.006	3	1
UCEC	ERK2 →	+0.210	+3.169	.015	.018	3	1
UCEC	JNK2 →	+0.226	+2.000	.011	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

eIF4E by GRAMD2B expression — UCEC

Explore this box plot interactively →