GRAMD2B

Across TCGA cell cohorts, GRAMD2B RNA expression is significantly associated with the go_rna of many other GO terms, with 5,150 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GRAMD2B-associated GO terms across cancer lineages are Membrane protein ectodomain proteolysis, Maintenance of protein localization in organelle, and Membrane protein proteolysis. Each is linked with GRAMD2B in more than 12 cancer types. Because this analysis shows association rather than direction, both GRAMD2B-to-partner and partner-to-GRAMD2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Membrane protein ectodomain proteolysis grouped by GRAMD2B-low versus GRAMD2B-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GRAMD2B→partner) and Y-score (partner→GRAMD2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Membrane protein ectodomain proteolysis →	+0.154	+2.166	<.001	<.001	3	13
SOFT_TISSUE	Maintenance of protein localization in organelle →	+0.174	+3.095	<.001	<.001	3	13
BONE	Membrane protein proteolysis →	+0.121	+2.111	.003	.001	3	13
BREAST	Positive regulation of purine nucleotide biosynthetic process →	+0.170	+1.427	<.001	.001	3	12
BREAST	Positive regulation of ATP biosynthetic process →	+0.168	+1.384	<.001	.001	3	12
BREAST	Positive regulation of nucleotide biosynthetic process →	+0.170	+1.427	<.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,150 associations by consensus.

Membrane protein ectodomain proteolysis by GRAMD2B expression — STOMACH

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