GRAMD2A

Across TCGA patient cohorts, GRAMD2A mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GRAMD2A-associated genes across cancer lineages are Caspase-8, eIF4E, and A-Raf_pS299. Each is linked with GRAMD2A in more than 1 cancer types. Because this analysis shows association rather than direction, both GRAMD2A-to-partner and partner-to-GRAMD2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-8 grouped by GRAMD2A-low versus GRAMD2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRAMD2A→partner) and Y-score (partner→GRAMD2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-8 →	-0.247	-2.295	.020	.033	3	2
UCEC	eIF4E →	+0.216	+2.222	.016	.011	3	1
UCEC	A-Raf_pS299 →	-0.149	-1.700	.003	.044	3	1
UCEC	JNK2 →	+0.292	+2.834	<.001	.034	3	1
UCEC	MSH2 →	-0.334	-3.295	<.001	.009	3	1
UCEC	N-Ras →	-0.136	-2.209	.007	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

Caspase-8 by GRAMD2A expression — UCEC

Explore this box plot interactively →