GRAMD2A

Across TCGA cell cohorts, GRAMD2A mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible GRAMD2A-associated genes across cancer lineages are MAPK_pT202_Y204, MEK1_p_S217_S221, and mTOR_pS2448. Each is linked with GRAMD2A in more than 1 cancer types. Because this analysis shows association rather than direction, both GRAMD2A-to-partner and partner-to-GRAMD2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAPK_pT202_Y204 grouped by GRAMD2A-low versus GRAMD2A-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRAMD2A→partner) and Y-score (partner→GRAMD2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MAPK_pT202_Y204 →	+0.745	+2.646	.001	.047	3	1
BREAST	MEK1_p_S217_S221 →	+0.493	+2.646	.010	.047	3	1
BREAST	mTOR_pS2448 →	+0.237	+2.646	.037	.047	3	1
BREAST	p70-S6K_pT389 →	+0.661	+2.646	.020	.047	3	1
BREAST	p90 RSK_pT573 →	+0.528	+2.646	.007	.047	3	1
BREAST	Collagen-VI →	+0.526	+2.646	.006	.047	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

MAPK_pT202_Y204 by GRAMD2A expression — BREAST

Explore this box plot interactively →