GRAMD1A

Across TCGA cell cohorts, GRAMD1A mutation is significantly associated with the RNA expression of many other genes, with 588 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRAMD1A-associated genes across cancer lineages are OR10G2, C12orf65, and LARP1B. Each is linked with GRAMD1A in more than 1 cancer types. Because this analysis shows association rather than direction, both GRAMD1A-to-partner and partner-to-GRAMD1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10G2 grouped by GRAMD1A-low versus GRAMD1A-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRAMD1A→partner) and Y-score (partner→GRAMD1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR10G2 →	+0.194	+4.772	<.001	.002	3	2
LARGE_INTESTINE	C12orf65 →	+0.470	+3.082	<.001	.007	3	2
LARGE_INTESTINE	LARP1B →	+0.588	+2.628	.006	.002	3	2
LARGE_INTESTINE	KLHL8 →	+0.614	+2.628	.002	.002	3	2
LARGE_INTESTINE	SKA1 →	+0.737	+3.743	.004	<.001	3	2
LARGE_INTESTINE	AASS →	+1.315	+2.628	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 588 associations by consensus.

OR10G2 by GRAMD1A expression — CNS

Explore this box plot interactively →