GRAMD1A

Across TCGA cell cohorts, GRAMD1A mutation is significantly associated with the mutation status of many other genes, with 4,165 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible GRAMD1A-associated genes across cancer lineages are HELZ2, INSR, and FLNA. Each is linked with GRAMD1A in more than 4 cancer types. Because this analysis shows association rather than direction, both GRAMD1A-to-partner and partner-to-GRAMD1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HELZ2 grouped by GRAMD1A-low versus GRAMD1A-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GRAMD1A→partner) and Y-score (partner→GRAMD1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	HELZ2 →	+2.754	+4.095	.009	.009	1	5
BLOOD_Lymphoma	INSR →	+4.014	+4.969	.008	.008	1	5
SKIN	FLNA →	+2.187	+3.169	.009	.009	1	5
SKIN	TPTE →	+2.394	+4.281	.001	.001	1	5
UPPER_AERODIGESTIVE_TRACT	HEPH →	+4.392	+4.954	.008	.008	1	5
BLOOD_Leukemia	COL5A1 →	+2.347	+2.807	.001	.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,165 associations by consensus.

HELZ2 by GRAMD1A expression — OVARY

Explore this box plot interactively →