GPX8

Across TCGA pan-cancer cohorts, GPX8 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GPX8 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher GPX8 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated GPX8 expression acts as an unfavorable survival marker.

CCRCC, PDAC, and LSCC are the cancer types where GPX8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Tertile	III,IV	0.480	0.917	.002	55	view →
PDAC	DFS	Quartile	III,IV	0.151	0.562	.004	34	view →
LSCC	DFS	Quartile	II,III,IV	0.636	0.915	.007	18	view →
UCEC	DFS	Tertile	II,III,IV	0.422	0.916	.014	14	view →
GBM	OS	Median	All	0.774	0.939	.025	5	view →
LUAD	DFS	Median	All	0.521	0.839	.018	4	view →
HNSC	DFS	Median	IV	0.581	0.801	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GPX8–CCRCC (OS)

Open the CCRCC breakdown →