GPX8

Across TCGA cell cohorts, GPX8 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,499 significant associations in total. BONE shows the largest number of these associations.

The most reproducible GPX8-associated GO terms across cancer lineages are Peptidyl-lysine oxidation, Collagen fibril organization, and Regulation of glutamate uptake involved in transmission of nerve impulse. Each is linked with GPX8 in more than 13 cancer types. Because this analysis shows association rather than direction, both GPX8-to-partner and partner-to-GPX8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peptidyl-lysine oxidation grouped by GPX8-low versus GPX8-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (GPX8→partner) and Y-score (partner→GPX8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Peptidyl-lysine oxidation →	+1.449	+3.136	<.001	<.001	3	14
LUNG_NSCLC_LUSC	Collagen fibril organization →	+0.299	+3.218	.008	.005	3	14
SOFT_TISSUE	Regulation of glutamate uptake involved in transmission of nerve impulse →	+0.245	+1.692	<.001	.001	3	14
SOFT_TISSUE	Regulation of plasminogen activation →	+0.348	+2.053	<.001	<.001	3	14
BONE	Regulation of proteolysis →	+0.177	+2.179	<.001	<.001	3	13
BONE	Maintenance of protein location in cell →	+0.125	+1.756	<.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,499 associations by consensus.

Peptidyl-lysine oxidation by GPX8 expression — STOMACH

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