GPX7

Across TCGA pan-cancer cohorts, GPX7 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated GPX7 data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher GPX7 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated GPX7 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

HNSC, UCEC, and COAD are the cancer types where GPX7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	IV	0.527	0.889	.004	28	view →
UCEC	DFS	Quartile	III,IV	0.248	1.000	.008	24	view →
COAD	DFS	Quartile	III,IV	0.757	1.000	.044	6	view →
LSCC	OS	Tertile	III,IV	0.608	0.995	.024	6	view →
PDAC	OS	Tertile	III,IV	0.255	0.564	.026	6	view →
GBM	DFS	Tertile	All	0.593	0.286	.021	6	view →
CCRCC	OS	Median	All	0.629	1.000	.002	4	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

GPX7–HNSC (DFS)

Open the HNSC breakdown →