GPX7

Across TCGA patient cohorts, GPX7 mutation is significantly associated with the RNA expression of many other genes, with 117 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPX7-associated genes across cancer lineages are RNU7-110P, RNU6-586P, and TSPY1. Each is linked with GPX7 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPX7-to-partner and partner-to-GPX7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-110P grouped by GPX7-low versus GPX7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPX7→partner) and Y-score (partner→GPX7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU7-110P →	+0.440	+2.608	.005	.004	3	2
BRCA	RNU6-586P →	+0.227	+7.731	<.001	.009	3	1
BRCA	TSPY1 →	+0.089	+8.471	<.001	.005	3	1
UCEC	MIR8082 →	+0.653	+3.339	<.001	<.001	3	1
UCEC	MIR6894 →	+0.786	+2.718	<.001	.001	3	1
CESC	PRAMEF11 →	+0.024	+5.969	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 117 associations by consensus.

RNU7-110P by GPX7 expression — UCEC

Explore this box plot interactively →