GPX7

Across TCGA patient cohorts, GPX7 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible GPX7-associated genes across cancer lineages are EGFR_pY1068, PKC-a_pS657, and PKC-a. Each is linked with GPX7 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPX7-to-partner and partner-to-GPX7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by GPX7-low versus GPX7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPX7→partner) and Y-score (partner→GPX7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.298	-3.321	.023	.010	3	1
UCEC	PKC-a_pS657 →	+0.523	+2.183	.009	.035	3	1
UCEC	PKC-a →	+0.677	+3.013	.001	.018	3	1
UCEC	p62 Lck ligand →	+0.523	+3.009	.002	.019	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

EGFR_pY1068 by GPX7 expression — UCEC

Explore this box plot interactively →