Across TCGA pan-cancer cohorts, GPX5 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated GPX5 data layer compared with 16 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher GPX5 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated GPX5 expression acts as an unfavorable survival marker.

READ and GBM are the cancer types where GPX5 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	All	0.281	0.823	<.001	9	view →
GBM	OS	Median	All	0.070	0.416	.003	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: GPX5 tumor-vs-normal RNA expression · all GPX5 data types