Across TCGA patient cohorts, GPX5 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible GPX5-associated genes across cancer lineages are EGFR_pY1173, MSH6, and AMPK_pT172. Each is linked with GPX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both GPX5-to-partner and partner-to-GPX5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (GPX5→partner) and Y-score (partner→GPX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1173 →	+0.085	+2.486	.027	.011	3	1
UCEC	MSH6 →	-0.349	-3.169	.028	.018	3	1
UCEC	AMPK_pT172 →	+0.462	+3.169	.020	.019	3	1
SKCM	Ku80 →	+0.314	+3.169	.022	.018	3	1
SKCM	MYH11 →	-0.953	-3.000	.026	.034	3	1
SKCM	S6_pS240_S244 →	+0.432	+2.824	.037	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

GPX5 survival (RNA) · tumor vs normal (RNA) · all GPX5 data types