GPX4

Across TCGA pan-cancer cohorts, GPX4 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated GPX4 data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher GPX4 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated GPX4 expression acts as an unfavorable survival marker.

BRCA, SCLC, and SARC are the cancer types where GPX4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	All	0.170	0.903	<.001	12	view →
SCLC	OS	Median	All	0.192	0.713	.001	12	view →
SARC	DFS	Median	All	0.065	0.632	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

GPX4–BRCA (DFS)

Open the BRCA breakdown →