GPX2

Across TCGA patient cohorts, GPX2 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,937 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible GPX2-associated proteins across cancer lineages are PPP1R18_S224, ALDH3A1, and ICAM1. Each is linked with GPX2 in more than 4 cancer types. Because this analysis shows association rather than direction, both GPX2-to-partner and partner-to-GPX2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, GPX2 versus PPP1R18_S224 in LSCC, with a Pearson correlation of -0.44.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (GPX2→partner) and Y-score (partner→GPX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PPP1R18_S224 →	-0.453	-1.649	<.001	<.001	3	5
LSCC	ALDH3A1 →	+2.112	+3.031	<.001	<.001	3	5
HNSC	ICAM1 →	-0.674	-2.642	<.001	<.001	3	5
COAD	RAB31 →	-0.449	-0.925	.001	.002	3	4
LSCC	STRBP →	+0.673	+2.589	<.001	<.001	3	4
LUAD	AKR1B10 →	+3.015	+2.554	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,937 associations by consensus.

GPX2 vs PPP1R18_S224 — LSCC

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